from assessment to treatment Lenzi, Andrea editor. Migliaccio, Silvia editor. text Electronic books. sz 2018 monographic eng 1 online resource. This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age. Intro; Preface; Introduction to Interdisciplinary Approach to Osteoporosis: Why Is It So Important?; Contents; 1: Anatomy and Physiology of Skeletal Tissue: The Bone Cells; 1.1 Introduction; 1.2 The Functions of the Bone; 1.3 Osteoclasts; 1.4 Osteoclastogenesis; 1.5 Osteoblasts; 1.6 Transcription Factors Affecting Osteoblastogenesis; 1.7 Molecules Affecting Osteoblastogenesis; 1.8 Osteocytes; 1.9 Osteocytogenesis; 1.9.1 Development and Maintenance of the Osteocytic Network; 1.9.2 Phosphate Metabolism and Matrix Mineralization; 1.9.3 Regulation of Bone Formation and Resorption 3.1.1 Genetic Factors3.1.2 Environmental Factors; 3.1.2.1 Alcohol; 3.1.2.2 Cigarette Smoking; 3.1.2.3 Physical Inactivity and Immobilization; 3.1.2.4 Low Body Weight and Diet; 3.1.2.5 Limited Exposure to Ultraviolet Light; 3.1.3 Reproductive History and Puberty; 3.1.4 Personal History of Fractures and Falls; 3.1.5 Drug Therapy; 3.1.6 Comorbidities; 3.1.7 Physical Examination; 3.1.8 Algorithms; 3.2 Laboratory Testing; 3.3 Bone Imaging; 3.3.1 Conventional X-ray of the Spine; References; 4: Functional Evaluation of the Subjects with Skeletal Alterations; 4.1 Introduction 4.2 Functional Evaluation4.2.1 Range of Motion; 4.2.2 Muscle Assessment; 4.2.2.1 Muscle Mass Assessment; 4.2.2.2 Muscle Strength Assessment; 4.2.2.3 Muscle Power and Physical Performance Assessment; 4.2.3 Balance Assessment; 4.2.4 Disability Assessment; 4.3 Pain Assessment; 4.4 Health-Related Quality of Life; References; Part I: Endocrinologicic and Metabolic Regulation; 5: Skeletal Alterations and Parathyroid Function; 5.1 Introduction; 5.2 Effect on Bone Resorption; 5.3 Effect on Bone Formation; 5.4 Primary Hyperparathyroidism; 5.5 Hypoparathyroidism 5.6 Effects of Parathyroid Hormone Treatment in HypoparathyroidismReferences; 6: GH/IGF-I and Bone; 6.1 Physiology; 6.2 Clinical Consequences of GH Excess and Deficiency in Humans; 6.2.1 Acromegaly; 6.2.2 GHD; References; 7: Adrenal Function and Skeletal Regulation; 7.1 Introduction; 7.2 Adrenal Gland Hormones; 7.3 Glucocorticoids and Bone Physiology; 7.4 Androgens and Bone Physiology; 7.5 Subclinical Hypercortisolism and the Bone; 7.6 Overt Hypercortisolism and the Bone; 7.7 Glucocorticoid Sensitivity and the Bone; 7.8 Congenital Adrenal Hyperplasia and the Bone Andrea Lenzi, Silvia Migliaccio, editors. Includes index. Osteoporosis Osteoporosis Diagnosis Osteoporosis Treatment HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Metabolism Orthopaedics & fractures Endocrinology RC931.O73 616.7/16 (OCoLC)1018041888 9783319751108 3319751107 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1886267 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1886267 N$T 180914 20200702121305.0 on1052566417 eng