indications, techniques, and results Small, William Jr editor. Tarbell, Nancy J. 1951- editor. Yao, Min (Radiation oncologist) editor. text bibliography Electronic books. nju 2017 Third edition. monographic eng 1 online resource. Clinical Radiation Oncology; Contents; Dedication; Preface; Contributors; Section 1 Scientific Foundations; 1 Basic Concepts of Clinical Radiation Oncology; Introduction; Planning and Preparation; Radiation Therapy in the Clinic; Combining Radiation Therapy with Surgery; Preoperative Radiation Therapy; Postoperative Radiation Therapy; Combining Radiation Therapy with Chemotherapy; Combining Radiation Therapy with Biologic Agents; Combining Radiation Therapy with Hormonal Agents; Radiosensitivity and Tumor Control Probability; Fractionation and Fraction Size Linear Energy Transfer (LET) and Relative Biologic Effectiveness (RBE)Oxygen Enhancement Ratio; Radiocurable Tumors; Technological Advances in Radiotherapy; Intensity-Modulated Radiation Therapy (IMRT); Image-Guided Radiotherapy (IGRT); Stereotactic Radiosurgery (SRS)/Stereotactic Body Radiation Therapy (SBRT); Particle Beam Radiotherapy; Brachytherapy; Intraoperative Radiotherapy; Unsealed Sources; Hyperthermia; Radiation Complications; References; 2 Radiation Biology for Radiation Oncologists; DNA Damage, DNA Repair, and Cell Survival; DNA Damage After Irradiation Immediate Biochemical Modification of Radiation-Induced DamageDNA Damage Sensing and DNA Repair; Modes of Cell Death Following DNA Damage; Biological Factors that Influence Radiation Response; The Oxygen Effect and the Significance of Hypoxia; Radiation Sensitivity, the Cell Cycle, and Checkpoints; Physical Parameters Affecting Radiation Response; Dose Rate; Linear Energy Transfer and Relative Biological Effectiveness; Tumor and Tissue Responses to Ionizing Radiation; Dose-Response Curves and the Therapeutic Window; Tumor Cell Radiation Sensitivity Dose-Response Curves for Tumors Irradiated In SituSlope of Dose-Response Curve and Heterogeneity in Treated Tumors; Tumor Volume and TCD50; Recurrent Tumors; Immune Reaction and Tumor Response; Normal Tissue Response; Attempts to Reduce the Impact of Hypoxic Cells on Tumor Resistance; Dose Fractionation and Tissue Response; Biological Significance of Dose Fractionation; Models of Fractionation Dependence; Combination of Radiation and Chemotherapeutic Agents: Cytotoxics, Sensitizers, and Protectors; Radiation Protectors; Rationale for the Combination of Surgery and Radiotherapy New Approaches to Optimize Radiation TherapyInhibition of Kinase-Dependent Signaling Pathways to Enhance Radiotherapy; Modulation of Apoptosis to Increase Tumor Cell Kill or Protect Normal Tissues; Angiogenesis as a Target for Cancer Therapy; Summary; References; 3 Treatment Planning; Introduction; Imaging; Imaging for Treatment Planning; Computed Tomography; Magnetic Resonance Imaging; Emission Tomography; Image Processing; Image Registration; Deformable Image Registration (DIR); Image Segmentation; Dose Calculations; Single-Field Dosimetry editor, William Small, Jr. ; associate editors, Nancy J. Tarbell, Min Yao ; section editors, Jason A. Efstathiou, Minesh P. Mehta, William Small, Jr., Christopher G. Willett, Min Yao. Includes bibliographical references and index. Cancer Radiotherapy HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Cancer Radiotherapy Neoplasms radiotherapy Radiation Oncology methods RC271.R3 616.99/40642 QZ 269 Hoboken, NJ : John Wiley & Sons, Inc., 2017 Third edition. (DLC) 2016039773 9781119341154 1119341159 2016040775 https://doi.org/10.1002/9781119341154 https://doi.org/10.1002/9781119341154 DLC 160902 20210825162445.0 ocn957705232 eng