Rice, Joseph E. creator text Electronic books. xx Burlington Elsevier Science 2014 monographic eng

electronic resource

1 online resource (219 p.) Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is g. Front Cover; Organic Chemistry Concepts and Applications for Medicinal Chemistry; Copyright; DEDICATION; CONTENTS; PREFACE; Chapter 1 -- Bonding in Organic Compounds; ATOMIC ORBITALS; HYBRID ORBITALS; RESONANCE; AROMATICITY; REFERENCE; Chapter 2 -- The Three-Dimensional Structure of Organic Compounds; ISOMERS; STEREOISOMERISM AT SATURATED CENTERS; PROCHIRALITY; STEREOISOMERISM AT UNSATURATED CENTERS; CONFORMATIONS; REFERENCE; Chapter 3 -- Functional Groups; COMMON FUNCTIONAL GROUPS; THE ELECTRONIC EFFECTS OF FUNCTIONAL GROUPS; REFERENCES; CHAPTER 4 -- ACIDS AND BASES*; IONIZATION ESTIMATING ACID/BASE STRENGTHLEWIS ACIDS AND BASES; Chapter 5 -- Partition Coefficients; WHAT IS A PARTITION COEFFICIENT?; EFFECT OF STRUCTURE ON PARTITION COEFFICIENTS; REFERENCE; Chapter 6 -- The Nomenclature of Cyclic and Polycyclic Compounds; COMMON HETEROCYCLES; FUSED-RING SYSTEMS; SUBSTITUENTS AND SATURATION; BRIDGED RINGS; SPIRO RINGS; SPECIAL CLASSES OF COMPOUNDS; Chapter 7 -- Drug Metabolism; PHASE I: OXIDATIVE PROCESSES; PHASE I: REDUCTIONS; PHASE I: HYDROLYSIS; PHASE II: CONJUGATION; MISCELLANEOUS PHASE II PROCESSES; REFERENCES; INDEX Description based upon print version of record. Clinical chemistry Biochemistry Organic compounds SCIENCE / Chemistry / Organic QD415 547 Rice, Joseph E. Burlington : Elsevier Science,c2014 9780128008324 (electronic bk.) 0128008326 (electronic bk.) https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=760687 https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=760687 EBLCP 140419 20230110113547.0 ocn877771869 eng